How MTHFR gene affects your body’s ability to process folate
The MTHFR 677T variant is associated with how the body metabolises folate. This B vitamin is crucial for bodily functions, such as cardiovascular health and DNA synthesis. A mutation in the 677 position can lower the enzyme’s effectiveness in converting homocysteine to methionine, a process vital for optimal heart health and overall cell function. People with this variation may have high homocysteine levels, which are linked to a risk of heart issues if not managed correctly.
Dealing with (Methylenetetrahydrofolate Reductase) MTHFR 677T usually requires changing your diet to maintain methylation support because folate processing may be compromised in this case scenario. The key is to incorporate methylfolate. The form of folate. And other beneficial nutrients, such as vitamins, including Methyl B12 and B6, into your daily intake. Over-the-counter vitamins are not suitable. It’s important for those with this genetic variation to limit artificial folic acid consumption and prioritise wholesome foods rich in nutrients to enhance well-being and alleviate symptoms linked to this genetic difference.
The MTHFR 677T gene variation may be linked to health problems because it affects methylation and detox processes in the body. Problems with methylation might result in increased levels that can cause inflammation and impact gut health. Moreover, decreased enzyme activity may lead to nutrient shortages like natural folate and B vitamins, essential for a healthy digestive system.
People with the MTHRF 677T variant may experience digestive discomfort, poor absorption, and imbalances in gut flora, with no diagnoses. Supporting methylation through Methylfolate vitamin B12 and a nutrient-rich diet can help manage gut issues linked to MTHFR 677T.
In addition to gut issues, the MTHFR 677T variant can lead to other symptoms due to reduced enzyme function and impaired methylation.
7 Common MTHFR 677T Elevated Homocysteine symptoms
- Fatigue and Brain Fog
- Mood Disorders
- Anxiety or OCD
- Depression or irritability
- Cardiovascular Problems
- High Blood Pressure
- Blood clotting disorders
Fertility Issues:
- Pregnancy problems or recurrent miscarriages
- Migraines and Headaches: Due to disrupted nitric oxide production
Gut Issues Symptoms
- Upper stomach ache
- Smelly Poo
- Constipation or Diarrhoea
- Loss of weight or Weight Gain
- Nutrient Deficiencies
- Leaky Gut
- Gut-Brain Axis Imbalance
- Depression comes and goes
- Feeling like you are in a black hole and can’t get out
- Food Sensitivities
- Histamine Intolerance
- Poor Digestive Enzyme Production
- Inflammation
- SIBO (Small Intestinal Bacterial Overgrowth)
If your homocysteine levels are normal or low, I know from personal experience that you can still experience the above symptoms. Supporting methylation pathways with the proper nutrients, vitamins, and lifestyle adjustments can help alleviate these symptoms.